In addition to antiviral therapies and vaccines, there will be a growing need for new therapeutic options for bacterial infections. Antimicrobial resistance (AMR) is the ability of a microorganism (like bacteria, viruses, and some parasites) to stop an antimicrobial (such as antibiotics, antivirals and antimalarials) from working against it. As a result, standard treatments become ineffective, infections persist and may spread to others.
The worldwide percentage of bacteria that are resistant to one or more antibiotics is rising. On a yearly basis it has been estimated that 700.000 deaths are caused by antimicrobial resistance (AMR review 2016).The top 3 of resistant bacteria from the WHO priority pathogen list 2017, belong to the group of Gram-negative pathogens, indicating that sufficient treatment strategies and effective antibiotics against Gram-negative bacteria are lacking.